Rhino-orbital-cerebral mucormycosis: management beyond surgery. Clinical case report and literature review
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Abstract
Introduction: It is the clinical case of a patient with rhino-orbital-cerebral mucormycosis
and the review of the literature. Clinical case: We present the case of a
previously healthy young man who started with sinonasal symptoms and hyphae
compatible with mucormycosis were found in the initial samples of outpatient care.
When he came to the institution, the infection had spread to all the nasal cavities
and part of the skull base. Discussion: Searching for baseline immunosuppression,
only difficult-to-control diabetes and de novo diagnosis were found. It required
multidisciplinary management, serial and extended surgeries, topical, venous and
oral antifungals. The prognosis improved and the evolution became favorable when
glycemic control was achieved. Conclusion: It is a fundamental requirement to carry
out a multidisciplinary work for the approach to these patients, both in the clinical,
surgical, psychosocial, nutritional and rehabilitation specialties.
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ISSN: 0120-8411
References
Ni Mhurchu E, Ospina J, Janjua AS, Shewchuk JR, Vertinsky AT. Fungal Rhinosinusitis: A Radiological Review With
Intraoperative Correlation. Can Assoc Radiol J. 2017;68(2):178-186. doi: 10.1016/j.carj.2016.12.009.
Raz E, Win W, Hagiwara M, Lui YW, Cohen B, Fatterpekar GM.Fungal Sinusitis. Neuroimaging Clin N Am. 2015;25(4):569-
doi: 10.1016/j.nic.2015.07.004.
Prakash H, Chakrabarti A. Global Epidemiology of Mucormycosis. J Fungi (Basel). 2019;5(1):26. doi: 10.3390/
jof5010026.
Plowes Hernández O, Prado Calleros HM, Soberón Marmissolle Daguerre GS, Sadek González A. Rhino-orbitocerebral
mucormycosis. Management strategies to avoid or limit intracraneal affection and improve survival. Acta
Otorrinolaringol Esp. 2015 Nov-Dec;66(6):348-52. doi:10.1016/j.otorri.2015.01.007.
Asano-Mori Y. Diagnosis and Treatment of Mucormycosis in Patients withHematological Malignancies (Translated Article).Med Mycol J. 2017;58(3):E97-E105. doi: 10.3314/mmj.17.013.
Wali U, Balkhair A, Al-Mujaini A. Cerebro-rhino orbital mucormycosis: an update. J Infect Public Health. 2012;5(2):116-
doi: 10.1016/j.jiph.2012.01.003.
Dimaka K, Mallis A, Naxakis SS, Marangos M, Papadas TA, Stathas T, et al. Chronic rhinocerebral mucormycosis: a rare case report and review of the literature. Mycoses. 2014;57(11):699-
doi: 10.1111/myc.12219.
Petrikkos G, Skiada A, Lortholary O, Roilides E, Walsh TJ,Kontoyiannis DP. Epidemiology and clinical manifestations of
mucormycosis. Clin Infect Dis. 2012;54 Suppl 1:S23-34. doi:10.1093/cid/cir866.
Kufer TA, Nigro G, Sansonetti PJ. Multifaceted Functions of NOD-Like Receptor Proteins in Myeloid Cells at the Intersection of Innate and Adaptive Immunity. Microbiol Spectr. 2016;4(4).doi: 10.1128/microbiolspec.MCHD-0021-2015.
Sánchez-Gil J, Guirao-Arrabal E, Parra-García GD, Luzón-García MDP, Fe Bautista-Marín M, Barayobre-Barayobre M,
et al. Nosocomial Rhinocerebral Mucormycosis: Two Cases with a Temporal Relationship. Mycopathologia. 2017;182(9-
:933-935. doi: 10.1007/s11046-017-0164-2.
Ferguson BJ. Invasive Fungal Rhinosinusitis The Manifestations of Fungal Rhinosinusitis According to Host Immunologic Status. En: Flint P, Haugey B, Lund V, Niparkd J, Richardson M, Robins KT, et al (editores). Cummings otolaryngology: Head and neck surgery. 5.a edición. Filadelfia: Mosby Elsevier;2010. p. 709-16.
Lagos A, Ferrada S, Muñoz T, Maul X, Finkelstein A, González C, et al. 10-year experience in patients operated for acute
invasive fungal rhinosinusitis. Acta Otorrinolaringol Esp (EnglEd). 2020;71(5):303-308. doi: 10.1016/j.otorri.2019.11.004.
Middlebrooks EH, Frost CJ, De Jesus RO, Massini TC, Schmalfuss IM, Mancuso AA. Acute Invasive Fungal
Rhinosinusitis: A Comprehensive Update of CT Findings and Design of an Effective Diagnostic Imaging Model. AJNR Am J
Neuroradiol. 2015;36(8):1529-35. doi: 10.3174/ajnr.A4298.
Yeo CD, Kim JS, Kwon SH, Lee EJ, Lee MH, Kim SG, et al. Rhinocerebral mucormycosis after functional endoscopic
sinus surgery: A case report. Medicine (Baltimore). 2018;97(51):e13290. doi: 10.1097/MD.0000000000013290.
Cuervo SI, Bermúdez CD, Enciso L, Gómez JC, Castillo JS, Sánchez R, et al. Guía de práctica clínica para el diagnóstico
y el tratamiento de las infecciones bacterianas y micóticas en pacientes oncológicos mayores de 15 años con neutropenia
febril posquimioterapia de alto riesgo. Rev Colomb Cancerol. 2014;18(4):186-96. doi: 10.1016/j.rccan.2014.06.002.