Peripheral eosinophilia as a factor of tomographic severity in chronic rhinosinusitis
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Abstract
Introduction: Chronic rhinosinusitis (CRS) is one of the most prevalent diseases worldwide. Eosinophils play an important role in the generation of a chronic nasosinusal inflammatory process secondary to the generation of a Th2 maladaptive response and changes in the nasal microbiota.
Objectives: To determine if peripheral eosinophilia can be used as a predictor of tomographic severity in patients with chronic rhinosinusitis.
Methods: An observational cross-sectional study with an analytical component was performed in patients with a diagnosis of CSR who had a eosinophil count in their clinical record. The sample size was 74 individuals.
Results: Peripheral eosinophilia was established as a tomographic severity factor, finding that for each increase of 100 eosinophils in blood, the total score of the Lund-Mackay tomographic scale would increase by 1 point. This pattern was equally concordant in patients with polyps and asthma, with increases in total scores of 4 and 5 points respectively, with respect to patients who do not present these pathologies.
Conclusion: The use of peripheral eosinophilia as a predictor of severity could be very useful for the medical community. This biomarker can result in potential cost savings by eliminating the need for repeated medical treatments in patients who initially have an increased risk of severe nasosinusal disease.
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Este artículo es publicado por la Revista Acta de Otorrinolaringología & Cirugía de Cabeza y Cuello.
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eISSN: 2539-0856
ISSN: 0120-8411
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