SMELL: oldest form of communication and precise sense that the otolaryngologist must know in depth

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Freddy Enrique Agredo Lemos
Gustavo Aldolfo Cuello Bueno

Abstract

Introduction: The key role of the ancient olfactory sensory system is to provide in[1]formation about chemicals in the environment. Smell plays a role in the detection of dangerous compounds, the maintenance of nutrition, interpersonal behavior, neuro[1]logical health, and the sensation of pleasure, among other functions. Consequently, olfactory dysfunction can lead to a risk of injury, malnutrition, social isolation, and a poor quality of life. Materials and methods: A bibliographical exploration was carried out and articles were identified according to the inclusion and exclusion criteria defined and those with quality evidence were taken. Discussion: The human olfactory system has considerable anatomical, physiological, and genetic differences from that of other mammals. Conclusions: Olfactory skills vary with factors such as age, sex, stage of development, certain ear, nose and throat diseases and general diseases.

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SMELL: oldest form of communication and precise sense that the otolaryngologist must know in depth. Acta otorrinolaringol cir cabeza cuello [Internet]. 2023 Jul. 14 [cited 2025 Sep. 6];51(2):137-42. Available from: https://revista.acorl.org.co/index.php/acorl/article/view/727

References

Gudziol H. Uber das Riechen [Sense of smell]. Laryngorhinootologie. 1995;74(2):122-4. German. doi: 10.1055/s-2007-997703

Nowak J, Januszkiewicz-Lewandowska D. Genetyczna determinacja wechu [Genetic determination of smell]. Otolaryngol Pol. 2001;55(6):575-9. Polish

Breer H, Fleischer J, Strotmann J. The sense of smell: multiple olfactory subsystems. Cell Mol Life Sci. 2006;63(13):1465-75. doi: 10.1007/s00018-006-6108-5

Meredith M. Human vomeronasal organ function: a critical review of best and worst cases. Chem Senses. 2001;26(4):433- 45. doi: 10.1093/chemse/26.4.433

Witt M, Wozniak W. Structure and function of the vomeronasal organ. Adv Otorhinolaryngol. 2006;63:70-83. doi: 10.1159/000093751

Megias M, Molist P, Pombal MA. Atlas de histologia vegetal y animal. Órganos de animales. Sentidos. [Internet]. 2018 [citado el 1 de febrero de 2023]. Disponible en: https://mmegias.webs. uvigo.es/descargas/o-a-sentidos.pdf

Crespo C, Liberia T, Blasco-Ibáñez JM, Nácher J, Varea E. Cranial Pair I: The Olfactory Nerve. Anat Rec (Hoboken). 2019;302(3):405-427. doi: 10.1002/ar.23816

Baraniuk JN, Merck SJ. New concepts of neural regulation in human nasal mucosa. Acta Clin Croat. 2009;48(1):65-73.

Buck L, Axel R. A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell. 1991;65(1):175-87. doi: 10.1016/0092-8674(91)90418-x

Glusman G, Yanai I, Rubin I, Lancet D. The complete human olfactory subgenome. Genome Res. 2001;11(5):685-702. doi: 10.1101/gr.171001

de Calvo OL. Fisiología del olfato. En: Fernández-Tresguerres JA, Ariznavarreta Ruiz C, Cachofeiro V, et al., eds. Fisiología humana. 4.a edición. México D.F: McGraw Hill Medical; 2010. Capítulo 18 p.236

Smith TD, Bhatnagar KP. Anatomy of the olfactory system. Handb Clin Neurol. 2019;164:17-28. doi: 10.1016/B978-0- 444-63855-7.00002-2

Hadley K, Orlandi RR, Fong KJ. Basic anatomy and physiology of olfaction and taste. Otolaryngol Clin North Am. 2004;37(6):1115-26. doi: 10.1016/j.otc.2004.06.009

Lynch PJ, medical illustrator; Jaffe CC, MD, cardiologist. File:Head olfactory nerve.jpg. Disponible en: https:// creativecommons.org/licenses/by/2.5/

Tran H, Chen H, Walz A, Posthumus JC, Gong Q. Influence of olfactory epithelium on mitral/tufted cell dendritic outgrowth. PLoS One. 2008;3(11):e3816. doi: 10.1371/journal. pone.0003816

Mennini A, The neurobiology of olfaction. CRC press Frontiers in Neuroscience[Internet]. Chapter 14 p,353

Branigan B, Tadi P. Physiology, Olfactory. 2023. En: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 enero–.

Kringelbach ML. The human orbitofrontal cortex: linking reward to hedonic experience. Nat Rev Neurosci. 2005;6(9):691- 702. doi: 10.1038/nrn1747

Gottfried JA, Small DM, Zald DH. The chemical senses. En: Zald D, Rauch S, eds. The Orbitofrontal Cortex. Oxford; 2006; online, Oxford Academic, 1 Feb. 2010. doi: 10.1093/acprof:o so/9780198565741.003.0006

Ehrlichman H, Bastone L. Olfaction and Emotion. En: Serby MJ, Chobor KL., eds. Science of Olfaction. New York, NY: Springer; 1992. doi: 10.1007/978-1-4612-2836-3_15

Pinto JM. Olfaction. Proc Am Thorac Soc. 2011;8(1):46-52. doi: 10.1513/pats.201005-035RN

Haddad R, Khan R, Takahashi YK, Mori K, Harel D, Sobel N. A metric for odorant comparison. Nat Methods. 2008;5(5):425- 9. doi: 10.1038/nmeth.1197

Marin C, Vilas D, Langdon C, Alobid I, López-Chacón M, Haehner A, et al. Olfactory Dysfunction in Neurodegenerative Diseases. Curr Allergy Asthma Rep. 2018;18(8):42. doi: 10.1007/s11882-018-0796-4

Haddad R, Carmel L, Sobel N, Harel D. Predicting the receptive range of olfactory receptors. PLoS Comput Biol. 2008;4(2):e18. doi: 10.1371/journal.pcbi.0040018

Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD. Odor coding by a Mammalian receptor repertoire. Sci Signal. 2009;2(60):ra9. doi: 10.1126/scisignal.2000016

Wise PM, Olsson MJ, Cain WS. Quantification of odor quality. Chem Senses. 2000;25(4):429-43. doi: 10.1093/ chemse/25.4.429

Doty RL, Shaman P, Applebaum SL, Giberson R, Siksorski L, Rosenberg L. Smell identification ability: changes with age. Science. 1984;226(4681):1441-3. doi: 10.1126/ science.6505700

Cain WS. To know with the nose: keys to odor identification. Science. 1979;203(4379):467-70. doi: 10.1126/science.760202

Keller A, Zhuang H, Chi Q, Vosshall LB, Matsunami H. Genetic variation in a human odorant receptor alters odour perception. Nature. 2007;449(7161):468-72. doi: 10.1038/nature06162

Deems DA, Doty RL, Settle RG, Moore-Gillon V, Shaman P, Mester AF, et al. Smell and taste disorders, a study of 750 patients from the University of Pennsylvania Smell and Taste Center. Arch Otolaryngol Head Neck Surg. 1991;117(5):519- 28. doi: 10.1001/archotol.1991.01870170065015

Boesveldt S, Postma EM, Boak D, Welge-Luessen A, Schöpf V, Mainland JD, et al. Anosmia-A Clinical Review. Chem Senses. 2017;42(7):513-23. doi: 10.1093/chemse/bjx025

Lötsch J, Kringel D, Hummel T. Machine Learning in Human Olfactory Research. Chem Senses. 2019;44(1):11-22. doi: 10.1093/chemse/bjy067

Lutterotti A, Vedovello M, Reindl M, Ehling R, DiPauli F, Kuenz B, et al. Olfactory threshold is impaired in early, active multiple sclerosis. Mult Scler. 2011;17(8):964-9. doi: 10.1177/1352458511399798

Hummel T, Rissom K, Reden J, Hähner A, Weidenbecher M, Hüttenbrink KB. Effects of olfactory training in patients with olfactory loss. Laryngoscope. 2009 Mar;119(3):496-9. doi: 10.1002/lary.20101

Lop Gros J, Iglesias Coma M, González Farré M, Serra Pujadas C. Alteraciones del olfato en la COVID-19, revisión de la evidencia e implicaciones en el manejo de la pandemia [Olfactory dysfunction in COVID-19, a review of the evidence and implications for pandemic management]. Acta Otorrinolaringol Esp. 2020;71(6):379-85. Spanish. doi: 10.1016/j.otorri.2020.04.003