CBX4: A Potential Presbycusis Therapeutic Gene Based on In Silico Study
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Abstract
Introduction: Presbycusis is a common form of hearing loss related with aging, characterized by the gradual loss of hearing capacity with time given the aging nature of the hearing system. A bioinformatic search was performed with the identification of Hub genes of potential biomarkers in the presbycusis development.
Methods: A dataset search on the repository GEO database with presbycusis as study objective, with expression profile GSE98070. GEO2R gene-analysis was performed with volcan plot filter, with common genes, functional richness analysis, protein-protein interaction network, and protein relevance.
Results: Of all 2040 gene sequences identified, 26 common genes were associated to presbycusis regulation in rodents. Principal interaction clusters towards genes YY1, CBX4, ELAVL1, SRSF7, and SRSF6 are intimately associated with presbycusis. CBX4 gene was selected as relevant from having a crystallographic structure and previous studies associating the gene in murine models and hearing loss.
Conclusion: In silico studies revealed a highly-associated presbycusis gene, CBX4, with potential future therapy target.
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